Vector illustration of multiparticulate capsule drug form

Multiparticulates

 
 
 

Miniature doses for outsized performance

Flexibility is a key attribute of multiparticulate dosage forms. Multiparticulate dosages can deliver unique drug release profiles, including combinations of controlled release drug delivery systems, sustained and extended release, from a single dose. 

Multiparticulate drug forms begin with a substrate such as sugar spheres, microcrystalline cellulose (MCC) spheres, or even the API itself.

  • The substrate is often coated with a film layer containing one or more APIs along with a suitable binder, such as hypromellose 
  • Finally, an optional release modifying film coating can be applied to achieve the desired drug release profile 
  • The finished multiparticulates can be loaded into hard shell capsules or combined with binders and compressed to form a tablet

DuPont offers a wide array of options for multiparticulates, leveraging its deep polymer expertise and technical bench strength.
 

Benefits of Multiparticulates:

  • A wide variety of release profiles are possible: Immediate Release, Controlled Release and pH dependent release profiles can be achieved or combined to create the desired profile
  • Reduced risk of dose dumping or dosage form manipulation
  • Easier to swallow and can be sprinkled onto food for patients with increased sensitivity

Here’s how we can deliver the functionality and variety you need for your multiparticulate formulations and we can help you determine how to navigate your needs for controlled and sustained release vs. extended release.

 
 
 

Product Recommendations*

Application

Recommended Products

Substrate

Avicel® PH spheres produced via extrusion spherionization

Drug Layering Binder

METHOCEL™ E3, E5, E6 or VLV Premium

Modified Release

Solvent Based

ETHOCEL™ Std 4, 7, 10, 14 Premium

Water Based

Dry Powder

Coascervation

ETHOCEL™ Std 45, 100 Premium

Tableting Binder

*Examples only and not representative of a complete list of recommended products or benefits.

 
 
 

Application Areas

We want to help you be successful in whatever application you are considering, so please contact us if you need more assistance.  Our experts are eager to tackle your challenges.

 
 
 

More Dosage Forms

  • Mucosal Bioadhesives
  • Oral Liquid Dosage
  • Topicals

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