Medicinal bottle and graduated cup with liquid solution, vector illustration.

Suspensions and Solutions

 
 
 

Improving patient experience and compliance

Better drug design and delivery options can help improve the likelihood that patients will be more willing to take their medications as prescribed.

Suspensions are defined as finely divided undissolved drugs dispersed in liquid vehicles. They can be a ready-to-use liquid suspension or a dry powder reconstitutable suspension, which is dispersed in water by the patient, a caregiver or a pharmacist. Solutions are defined as liquid preparations in which the drug and the various excipients are dissolved in the suitable solvent or aqueous system.

In these formulations, several of the following ingredients are typically added to support the delivery and experience of the API, including:

  • Suspending agent and/or viscosifier
  • Protective colloid
  • Wetting agent
  • Buffer and/or sequestrant
  • Preservative
  • Sweetener, coloring agent and flavor

IFF can help you differentiate your offerings in this category with specialized solutions that deliver key functionalities.

  • Avicel® colloidal MCC is produced by co-processing microcrystalline cellulose (MCC) and sodium carboxymethylcellulose (NaCMC). It is used in pharmaceutical suspensions, emulsions, nasal sprays, and creams. The wide range of thixotropies, viscosities, gel strengths, and dispersion characteristics of this product line deliver unparalleled functional versatility and physical stability of suspensions.
  • GRINDSTED® Xanthan gum is a very effective thickener and suspending agent. It provides desired rheological characteristics and ensures formulation homogeneity at very low use levels. Improved sensory attributes, like appealing mouthfeel, is another reason to include this excipient in liquid dosage forms.
  • TEXTURECEL™ sodium carboxymethylcellulose (NaCMC) controls the rheological (flow) properties in a variety of liquid dosage forms. It is an excellent choice for viscosity control, suspension stabilization, improved mouthfeel, water absorption or water retention as required.
  • METHOCEL™ water-soluble cellulose ethers are excellent thickeners, suspend solids, lubricate and retain moisture. The protective colloid action and emulsifying properties of METHOCEL™ cellulose ethers also benefit many liquid formulations.

Benefits of Suspensions and Solutions:

  • Preferred for patients, geriatric and pediatric, who have difficulty in swallowing solids such as tablets and capsules.
  • Bioavailability is usually higher than with most of the other delivery forms.
  • Improved chemical stability compared to other solutions.
  • Unpleasant taste can often be overcome by purposefully limiting the amount of drug in solution and by flavoring the liquid vehicle.

Here’s how we can deliver the functionality and variety you need for your suspension and solution formulations.

 
 
 

Product Recommendations*

Dosage form

Functionality

Product Recommendation

Suspensions

Rheology modifier, stability improvement, thixotropy 

Avicel® RC-591, Avicel® CL-611

GRINDSTED® Xanthan 80 PRM+, GRINDSTED® Xanthan 200 PRM+, GRINDSTED® Xanthan Easy PRM, GRINDSTED® Xanthan Clear 80 PRM

TEXTURECEL™ 1,000 PA 07, TEXTURECEL™ 2,000 PA 07, TEXTURECEL™ PRM 2,400 PA 07, TEXTURECEL™ 4,000 PA 07, TEXTURECEL™ 20,000 PA 07

METHOCEL™ E5 PRM, METHOCEL™ E4M PRM, METHOCEL™ K4M PRM

METHOCEL™ A4M PRM

Protanal® CR8133, Manucol® LKX

Gelcarin® and Viscarin® carrageenan

Solutions

Rheology modifier 

METHOCEL™ LV cellulose ethers

TEXTURECELTM NaCMC

GRINDSTED® Xanthan

Protanal®, Manucol®, Manugel®, Protanal® ester alginates

Gelcarin®, Viscarin®, and SeaSpen® carrageenan

*Examples only and not representative of a complete list of recommended products or benefits.

 
 
 

Application Areas

We want to help you be successful in whatever application you are considering, so please contact us if you need more assistance.  Our experts are eager to tackle your challenges.

 
 
 

For more information, download:

Liquid and Semi-Solid Applications Handout

 
 
 

Products

Various pharmaceutical tablets and capsules
The premier microcrystalline cellulose (MCC) for tablet binders and suspension aids
topicals 2.png
Delivering efficient and robust formulations
Water soluble polymers for pharmaceutical applications.
Versatile, marketing-leading excipient for a nearly endless number of pharma applications
Oral liquid dosage image.png
Versatile product for solid, semi-solid and liquid dosage forms
 
 
 

More Dosage Forms and Applications

DF4.png
Solutions for the formulation of tablets to support manufacturing complexities – OSD processes, functionality and bioavailability.
DF2.png
Plant-based ingredients to formulate solid oral dosage forms in an array of capsule sizes.
DF3.png
Deliver miniature doses with massive performance in a variety of release profiles and unique drug form combinations.
DF5.png
Additional dosage form solutions include: dissolving medication strips, thin film drug delivery, topical applications and more.
8-shutterstock_778917370-resized.jpg
Using our expertise to deliver results across interesting applications

Get Started

DuPont cares about your privacy. Your personal information (name, email, phone number and other contact data) will be stored in chosen customer systems primarily hosted in the United States. This information will be used by DuPont, its affiliates, partners, and selected third parties in other countries to provide you with the product or service information requested. To learn more, please visit www.privacy.dupont.com. By providing your personal information, you agree to the terms and conditions of this Privacy Statement.

 
 
 
/content/dupont/amer/us/en/nutrition-biosciences/contact-us.html /content/dupont/amer/us/en/nutrition-biosciences/references/corporate-contact-us.html /content/dupont/amer/us/en/nutrition-biosciences/references/subscribe.html