Hot-Melt Extrusion

Hot-Melt extrusion (HME) is gaining popularity in pharma for continuous processing and the advantages it offers for the formulation of APIs that are difficult to process and to deliver.

Enabling Technologies

AFFINISOL™ hypromellose acetate succinate (HPMCAS) is an excellent polymer for the formation of solid dispersions. It helps to maintain stable solid dispersions and inhibit API crystallization in solution, promoting supersaturation of the drug.

AFFINISOL™ HPMCAS offers flexibility in acetate and succinate substitution levels, facilitating the optimization of both solubility enhancement and material processing.

AFFINISOL™ HPMC HME is a readily extrudable hydroxypropyl methylcellulose, with processing versatility that requires no plasticizer. It is tailored for solubility enhancement and can offer controlled release formulations produced by HME. While it is capable of being extruded where current HPMC materials fail, it has been designed without modification of the HPMC backbone trusted for safety and performance.

ETHOCEL™ is a versatile and powerful tool in hot-melt extrusion of pharmaceutical formulations, allowing researchers to obtain specific release profiles while producing a wide variety of final dosage forms, including tablets, multiparticulates and core-sheath systems.

POLYOX™ resins extrude extremely well and can easily be used in other types of heat treatments. Many abuse-deterrent technologies take advantage of this property. Easy to use in conventional equipment, POLYOX™ also offers good flow characteristics. POLYOX™ has great film-making properties and can be used in a wide range of temperatures.


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