Osmotic Pump Technology

Reliable and Reproducible Zero Order Drug Release with POLYOX™

Osmotic pump technology is a well-recognized method of producing reliable and reproducible controlled release drug delivery formulations, showing clear advantages including clinical robustness; constant, prolonged delivery within the body; zero order release; and less impact from variables like gastrointestinal motility or food effects.

Enabling Technologies

Osmotic pump delivery systems are typically produced on a bi-layer tablet press and subsequently coated with a semipermeable membrane. Versatile and highly swellable POLYOX™ water-soluble resins help with the production of osmotic pump technologies: High-molecular-weight POLYOX™ is used to formulate the push layer, whereas the pull layer contains low-molecular-weight POLYOX™ and the API.

Related Formulation Technology

Dry Process

Granulation

Hot-Melt Extrusion

Spray-Dried Dispersions

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