API Stability

Some active pharmaceutical ingredients (APIs) are sensitive to the effects of heat, light and oxygen. DuPont offers solutions to protect APIs from environmental conditions and increase the stability of the ingredients in liquid suspensions to guarantee a drug’s long-term quality, efficacy and safety.

Solutions for API Stability:

METHOCEL™ POLYMERS – These can be used as thickeners, binders, film-formers and for water-retention in a number of pharmaceutical applications. METHOCEL™ products increase the stability of liquid suspensions

AMBERLITE™ - Liquid suspensions such as antibiotics, insulin and vaccines are produced through a series of separation and purification steps. AMBERLITE™ resins can enable high performance purification and separation operations. By creating a stable amorphous form, AMBERLITE™ resins can also prevent polymorphism which occurs when drugs change from one crystalline or amorphous form to another.

 
 
 

Related Applications

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Dow’s excipients for drug abuse deterrence applications provide tamper resistant properties.
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Suspensions are pharmaceutically stable dispersions of an insoluble or sparingly-soluble drug in a liquid vehicle, usually an aqueous solution. They can be ready-to-use or reconstitutable, where the drug is mixed with other ingredients in the dry state and reconstituted with water at the time of dispensing to the patient.
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Use of Avicel® DG dramatically increases tablet hardness, improves yields and provides good flow and a robust ribbon during the initial compaction phase
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Dow’s excipients for the nasal administration of pharmaceuticals.
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Rheology modifier, dosage form, liquid dosage forms, semi-solid formulations, thickeners, topical applications, thickening agent, Dow, Dow Pharma Solutions, METHOCEL, WALOCEL
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Dow’s portfolio of solubility enhancing excipients for drug compounds with low aqueous solubility.
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Dow’s excipients for film tablet coatings are tough, printable, economical and highly consistent.
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Dow’s excipients for taste masking applications in the oral drug delivery of tablets.
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Topical formulations enable local delivery of a drug to a specific site of action without systemic exposure and may be creams, gels, or sprays.

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