Capsules

Innovative Soft Capsules - Alginate Capsule Technology

Utilizing a novel patented process (alginate) this technology provides a unique seamless, enteric, vegetarian alternative to gelatin soft capsules in one unit process for pharmaceutical and nutraceutical applications.

Alginate capsules advantages:

Globally acceptable regulatory compliance with Vegetarian (gelatin-free)
Capsules easier to swallow:
Smaller Capsule: Seamless thinner capsule shell, allowing for capsules 30% smaller than traditional gelatin for a given fill volume
No Fish Burps: Naturally enteric providing superior gastro resistant and enteric release properties to film coated alternatives
Superior elegance - high shell transparency
Sugar and gluten free

Manufacture of capsules easier:

Favorable unit cost - process does not produce waste ribbon as seen in traditional rotary die processes and eliminates need/cost of enteric film coating maximizing production efficiency
Process designed to provide oxidation protection
QbD development philosophy
Patented product and process enables product life cycle enhancement.
IP Protected

Capabilities:

Laboratory scale process enables:
Technology demonstrations
Formulation development support
Product concept assessment
Sample manufacture for in vitro and stability assessment

Proven GMP capability:

Small GMP batches for early in vivo testing

Related Applications

Abuse Deterrence

Dow’s excipients for drug abuse deterrence applications provide tamper resistant properties.

API Stability

Dow offers solutions to protect APIs from environmental conditions and increase the stability of a drug’s long-term quality, efficacy and safety

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Dental Applications

Alginate-based impressions are attractive as orthodontic study models for a variety of reasons. These are fast setting at room temperature, easy to prepare, and very cost effective.

Enteric Coating

Dow’s excipients for the enteric coating of pharmaceutical tablets.

Enteric Drug Delivery

An enteric coating resists disintegration in the low pH of the stomach and is dissolved in the neutral pH environment of the intestine

Immediate Release - Liquids and Suspensions

Suspensions are pharmaceutically stable dispersions of an insoluble or sparingly-soluble drug in a liquid vehicle, usually an aqueous solution. They can be ready-to-use or reconstitutable, where the drug is mixed with other ingredients in the dry state and reconstituted with water at the time of dispensing to the patient.

Immediate Release – Tablets

Use of Avicel® DG dramatically increases tablet hardness, improves yields and provides good flow and a robust ribbon during the initial compaction phase

Modified Release

Dow’s excipients for controlled or modified release tablet and capsule formulations.

Nasal Delivery

Dow’s excipients for the nasal administration of pharmaceuticals.

Organoleptic Enhancements

Chewable tablets as a dosage form are growing in popularity. Palatable chewable tablets offer convenience for customers, broaden the applicability of formulations to pediatric or geriatric markets, and increase patient compliance

Rheology Modifiers

Rheology modifier, dosage form, liquid dosage forms, semi-solid formulations, thickeners, topical applications, thickening agent, Dow, Dow Pharma Solutions, METHOCEL, WALOCEL

Solubility Enhancement

Dow’s portfolio of solubility enhancing excipients for drug compounds with low aqueous solubility.

Tablet Coating

Dow’s excipients for film tablet coatings are tough, printable, economical and highly consistent.

Taste-Masking

Dow’s excipients for taste masking applications in the oral drug delivery of tablets.

Topical Preparations

Topical formulations enable local delivery of a drug to a specific site of action without systemic exposure and may be creams, gels, or sprays.

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