Immediate Release – Tablets

Roller Compaction

Roller Compaction is a dry process involving compaction of materials into ribbons which are then milled to generate a granulation. This granulation is then compressed on a tablet machine. This process can be used with moisture-sensitive active pharmaceutical ingredients (API's), it improves particle size and flow, and is readily adaptable to continuous processing. Use of Avicel® DG:

  • Dramatically increases tablet hardness

  • Provides good flow and a robust ribbon during the initial compaction phase

  • Reduces the number of excipients in the formulation and eliminates process steps

  • Improves yields

Recommended Products:

Avicel® DG in the intra-granular phase and no extra-granular binders required.

Direct Compression

Direct compression is the most economic process for the manufacture of tablets. Excipients are blended with the active and compressed with no need for drying. The process is suitable for use with moisture-sensitive actives but is more subject to segregation than the wet granulation approach. Avicel® PH grades provide excipient solutions to many challenges of direct compression formulations including:

  • Improved flow

  • Better compressibility

  • Accommodation of moisture-sensitive actives

Recommended Products:

Avicel® PH-102 SCG

Avicel® HFE-102

Avicel® PH-200

Avicel® PH-302

Wet Granulation

The earliest technology for granulating and processing drugs for tableting, this approach enables a uniform blend and avoids segregation. The addition of Avicel® PH 101 or PH 302 in wet granulation promotes:

  • Rapid, even wetting as a result of the wicking action of microcrystalline cellulose

  • Reduced sensitivity of the wet mass to over-wetting

  • Faster drying

  • Fewer screen blockages or case hardenings

  • Reduce dye migration

  • Faster disintegration

Recommended Products:

Avicel® PH-101

Avicel® PH-301

Disintegration

Super-disintegrants break a tablet into smaller fragments increasing the surface area of the dosage form and the rate of drug absorption. Ac-Di-Sol® Croscarmellose sodium is developed to:

  • Enhance drug dissolution by speeding tablet disintegration

  • Provide the highest level of disintegration force at low use levels

  • Utilize dual disintegration mechanisms of wicking and swelling for more rapid disintegration

Recommended Products:

Ac-Di-Sol®

Related Applications

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Dow’s excipients for the enteric coating of pharmaceutical tablets.

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An enteric coating resists disintegration in the low pH of the stomach and is dissolved in the neutral pH environment of the intestine

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Dow’s excipients for controlled or modified release tablet and capsule formulations.

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Dow’s excipients for the nasal administration of pharmaceuticals.

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Rheology modifier, dosage form, liquid dosage forms, semi-solid formulations, thickeners, topical applications, thickening agent, Dow, Dow Pharma Solutions, METHOCEL, WALOCEL

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Dow’s portfolio of solubility enhancing excipients for drug compounds with low aqueous solubility.

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Dow’s excipients for film tablet coatings are tough, printable, economical and highly consistent.

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Dow’s excipients for taste masking applications in the oral drug delivery of tablets.

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Topical formulations enable local delivery of a drug to a specific site of action without systemic exposure and may be creams, gels, or sprays.

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