Nasal Delivery

Nasal drug delivery has been in use for many years, primarily for the delivery of small molecules for use in respiratory and allergic rhinitis. Nasal drug delivery offers an alternative route of administration over injection.

Solutions for Nasal Delivery:

METHOCEL™ Cellulose Ethers have unique capabilities to control solution viscosity, direct drug spray pattern and retain drug on the mucosa to allow for permeation. These are key requirements for the deposition and delivery of small molecules & biologics.

POLYOX™ resins offers a number of important properties for mucoadhesion, including water solubility, hydrophilicity, high molecular weight, hydrogen bonding functionality, and good biocompatibility. Their long linear chain structure helps them to form a strong interpenetrating network with mucus. The polymer can be used in nasal solution applications.

Related Applications

Abuse Deterrence

Dow’s excipients for drug abuse deterrence applications provide tamper resistant properties.

API Stability

Dow offers solutions to protect APIs from environmental conditions and increase the stability of a drug’s long-term quality, efficacy and safety

Capsules

Utilizing a novel patented process (alginate) this technology provides a unique seamless, enteric, vegetarian alternative to gelatin soft capsules in one unit process for pharmaceutical and nutraceutical applications.

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Dental Applications

Alginate-based impressions are attractive as orthodontic study models for a variety of reasons. These are fast setting at room temperature, easy to prepare, and very cost effective.

Enteric Coating

Dow’s excipients for the enteric coating of pharmaceutical tablets.

Enteric Drug Delivery

An enteric coating resists disintegration in the low pH of the stomach and is dissolved in the neutral pH environment of the intestine

Immediate Release - Liquids and Suspensions

Suspensions are pharmaceutically stable dispersions of an insoluble or sparingly-soluble drug in a liquid vehicle, usually an aqueous solution. They can be ready-to-use or reconstitutable, where the drug is mixed with other ingredients in the dry state and reconstituted with water at the time of dispensing to the patient.

Immediate Release – Tablets

Use of Avicel® DG dramatically increases tablet hardness, improves yields and provides good flow and a robust ribbon during the initial compaction phase

Modified Release

Dow’s excipients for controlled or modified release tablet and capsule formulations.

Organoleptic Enhancements

Chewable tablets as a dosage form are growing in popularity. Palatable chewable tablets offer convenience for customers, broaden the applicability of formulations to pediatric or geriatric markets, and increase patient compliance

Rheology Modifiers

Rheology modifier, dosage form, liquid dosage forms, semi-solid formulations, thickeners, topical applications, thickening agent, Dow, Dow Pharma Solutions, METHOCEL, WALOCEL

Solubility Enhancement

Dow’s portfolio of solubility enhancing excipients for drug compounds with low aqueous solubility.

Tablet Coating

Dow’s excipients for film tablet coatings are tough, printable, economical and highly consistent.

Taste-Masking

Dow’s excipients for taste masking applications in the oral drug delivery of tablets.

Topical Preparations

Topical formulations enable local delivery of a drug to a specific site of action without systemic exposure and may be creams, gels, or sprays.

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