Solubility Enhancement

Trends in drug characteristics increasingly favor greater degrees of lipophilicity, higher molecular weight, greater physical form complexity and significantly lower aqueous solubility. Consequently, many chemical entities in drug development pipelines have poor water solubility.

Low aqueous solubility severely limits a compound’s bioavailability and therefore also limits the commercial viability of a new product. As a consequence, many active pharmaceutical ingredients that could potentially help cure diseases and improve consumers’ lives never enter the market.

Enabling Technologies

DuPont is committed to addressing the solubilization performance requirements of your APIs with a portfolio of tailored AFFINISOL™ polymers.

AFFINISOL™ hypromellose acetate succinate (AFFINISOL™ HPMCAS) is an excellent polymer for the formation of solid dispersions. It helps in maintaining stable solid dispersions and inhibiting API crystallization in solution, promoting supersaturation of the drug. AFFINISOL™ HPMCAS, either in spray drying or hot-melt extrusion, offers flexibility in acetate and succinate substitution levels, facilitating the optimization of both solubility enhancement and material processing.

AFFINISOL™ High Productivity (HP) HPMCAS is a lower-viscosity HPMCAS designed to further improve the utility of  AFFINISOL™ HPMCAS for spray-dried dispersion, hot-melt extrusion and top-spray granulation.

AFFINISOL™ HPMC HME is a readily extrudable hydroxypropyl methylcellulose with processing versatility that requires no plasticizer. It is tailored for solubility enhancement and can offer controlled release formulations produced by HME. While it is capable of being extruded where current HPMC materials fail, it has been designed without modification of the HPMC backbone trusted for safety and performance.

AMBERLITE™ and DUOLITE™ resins can be used to enhance the solubility and disintegration of poorly soluble drugs. In the case of poorly soluble ionizable drugs, the release of drug from a resinate can be faster than the rate of dissolution of the solid form of the drug. Hence, with AMBERLITE™ or DUOLITE™ AP, one can increase the rate at which poorly soluble drugs dissolve.

 
 
 

Related Applications

Thumb_Excipients_AbuseDeterrence.jpg

Dow’s excipients for drug abuse deterrence applications provide tamper resistant properties.

Thumb_Excipients_APIStability.jpg

Dow offers solutions to protect APIs from environmental conditions and increase the stability of a drug’s long-term quality, efficacy and safety

yellow_capsules_shutterstock_56239201_3_Card_Layout.png

Utilizing a novel patented process (alginate) this technology provides a unique seamless, enteric, vegetarian alternative to gelatin soft capsules in one unit process for pharmaceutical and nutraceutical applications.

mother_and_daughter_shutterstock_15995386_3Card_Layout.png

Alginate-based impressions are attractive as orthodontic study models for a variety of reasons. These are fast setting at room temperature, easy to prepare, and very cost effective.

4.2.9_Thumb_enteric_coating.jpg

Dow’s excipients for the enteric coating of pharmaceutical tablets.

shutterstock_562215688_3_cart_Layout.png

An enteric coating resists disintegration in the low pH of the stomach and is dissolved in the neutral pH environment of the intestine

iStock-179133772.png

Suspensions are pharmaceutically stable dispersions of an insoluble or sparingly-soluble drug in a liquid vehicle, usually an aqueous solution. They can be ready-to-use or reconstitutable, where the drug is mixed with other ingredients in the dry state and reconstituted with water at the time of dispensing to the patient.

shutterstock_564214432_3_cart_Layout.png

Use of Avicel® DG dramatically increases tablet hardness, improves yields and provides good flow and a robust ribbon during the initial compaction phase

shutterstock_373422979_3_cart_Layout.png

Dow’s excipients for controlled or modified release tablet and capsule formulations.

4.2.10_Thumb_nasal_delivery.jpg

Dow’s excipients for the nasal administration of pharmaceuticals.

iStock-582280216.png

Chewable tablets as a dosage form are growing in popularity. Palatable chewable tablets offer convenience for customers, broaden the applicability of formulations to pediatric or geriatric markets, and increase patient compliance

Thumb_Excipients_RheologyModifier.jpg

Rheology modifier, dosage form, liquid dosage forms, semi-solid formulations, thickeners, topical applications, thickening agent, Dow, Dow Pharma Solutions, METHOCEL, WALOCEL

4.2.3_Thumb_tabelt_coating.jpg

Dow’s excipients for film tablet coatings are tough, printable, economical and highly consistent.

Thumb_Applications_TasteMasking.jpg

Dow’s excipients for taste masking applications in the oral drug delivery of tablets.

iStock-467924581.png

Topical formulations enable local delivery of a drug to a specific site of action without systemic exposure and may be creams, gels, or sprays.

Get Started

DuPont cares about your privacy. Your personal information (name, email, phone number and other contact data) will be stored in chosen customer systems primarily hosted in the United States. This information will be used by DuPont, its affiliates, partners, and selected third parties in other countries to provide you with the product or service information requested. To learn more, please visit www.privacy.dupont.com. By providing your personal information, you agree to the terms and conditions of this Privacy Statement.

 
 
 
/content/dupont/amer/us/en/nutrition-biosciences/references/contact-us.html /content/dupont/amer/us/en/nutrition-biosciences/references/corporate-contact-us.html /content/dupont/amer/us/en/nutrition-biosciences/references/subscribe.html