The taste of orally delivered drugs is extremely important to encourage patient acceptability and compliance. Acceptable taste can help to determine market penetration and the commercial success of a new active pharmaceutical ingredient or a new dosage form. Unfortunately, the majority of orally administered, moderately water-soluble drugs are inherently very bitter. This is especially problematic with pediatric suspensions, since children are more sensitive to taste than adults. Hence, the ability to taste-mask is an important consideration for drug formulators.

Enabling Technologies

With DuPont AMBERLITE™ and DUOLITE™ resins, the drug is not released in the mouth, minimizing negative taste experience. When in contact with gastrointestinal fluids, the drug is released and then absorbed in the usual way. The resin passes through the GI tract without being absorbed.

ETHOCEL™ ethylcellulose polymers can be formulated into either clear or opaque films of varying thicknesses, for

different dissolution rates and taste-masking functionality.

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