Solubility Enhancement

Trends in drug characteristics increasingly favor greater degrees of lipophilicity, higher molecular weight, greater physical form complexity and significantly lower aqueous solubility. Consequently, many chemical entities in drug development pipelines have poor water solubility.

Low aqueous solubility severely limits a compound’s bioavailability and therefore also limits the commercial viability of a new product. As a consequence, many active pharmaceutical ingredients that could potentially help cure diseases and improve consumers’ lives never enter the market.

Enabling Technologies

DuPont is committed to addressing the solubilization performance requirements of your APIs with a portfolio of tailored AFFINISOL™ polymers.

AFFINISOL™ HPMC HME is a readily extrudable hydroxypropyl methylcellulose with processing versatility that requires no plasticizer. It is tailored for solubility enhancement and can offer controlled release formulations produced by HME. While it is capable of being extruded where current HPMC materials fail, it has been designed without modification of the HPMC backbone trusted for safety and performance.

AMBERLITE™ and DUOLITE™ resins can be used to enhance the solubility and disintegration of poorly soluble drugs. In the case of poorly soluble ionizable drugs, the release of drug from a resinate can be faster than the rate of dissolution of the solid form of the drug. Hence, with AMBERLITE™ or DUOLITE™ AP, one can increase the rate at which poorly soluble drugs dissolve.


Related Applications

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Dow’s excipients for the enteric coating of pharmaceutical tablets.
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Dow’s excipients for controlled or modified release tablet and capsule formulations.
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Chewable tablets as a dosage form are growing in popularity. Palatable chewable tablets offer convenience for customers, broaden the applicability of formulations to pediatric or geriatric markets, and increase patient compliance
Rheology modifier, dosage form, liquid dosage forms, semi-solid formulations, thickeners, topical applications, thickening agent, Dow, Dow Pharma Solutions, METHOCEL, WALOCEL
Dow’s excipients for film tablet coatings are tough, printable, economical and highly consistent.
Dow’s excipients for taste masking applications in the oral drug delivery of tablets.
Topical formulations enable local delivery of a drug to a specific site of action without systemic exposure and may be creams, gels, or sprays.

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