Solving the Insoluble


What is it?

AFFINISOL™ Hydroxypropyl Methyl Cellulose (HPMC) is a soluble polymer that can help optimize solubility enhancement by maintaining stable solid dispersions and inhibiting API crystallization.

What is it used for?

More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. Solid dispersions are the key technology to formulate oral solid dosage forms addressing bioavailability challenges. AFFINISOL™ polymers have been specifically designed for formulating solid dispersions via spray-drying (SDD) or hot-melt extrusion (HME).

AFFINISOL™ HPMC HME offers hot melt-extrusion process flexibility in choosing a polymer viscosity for optimization of both solubility enhancement and drug release profiles. The polymer’s added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications.

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