Solving the Insoluble


What is it?

AFFINISOL™ Hypromellose Acetate Succinate (HPMCAS) and AFFINISOL™ Hydroxypropyl Methyl Cellulose (HPMC) are soluble polymers that can help optimize solubility enhancement by maintaining stable solid dispersions and inhibiting API crystallization.

What is it used for?

More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. Solid dispersions are the key technology to formulate oral solid dosage forms addressing bioavailability challenges. AFFINISOL™ polymers have been specifically designed for formulating solid dispersions via spray-drying (SDD) or hot-melt extrusion (HME).

AFFINISOL™ HPMCAS is soluble in a wide range of organic solvents, which makes it compatible with a range of APIs and suitable for SDD. Additionally, AFFINISOL™ HPMCAS has a pH-dependent solubility in aqueous media, allowing for targeted delivery of an active.

AFFINISOL™ High Productivity HPMCAS has been developed to give the same solubility enhancement performance of AFFINISOL™ HPMCAS, while helping to improve the spray-drying-solution throughput during manufacturing.

AFFINISOL™ HPMC HME offers hot melt-extrusion process flexibility in choosing a polymer viscosity for optimization of both solubility enhancement and drug release profiles. The polymer’s added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications.


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