AFFINISOL™ hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization.
More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. AFFINISOL™ HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry.
AFFINISOL™ HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. The polymer’s added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications.
The application possibilities are endless. We want to help you be successful in whatever application you are considering, so please contact us if you need more assistance. Our experts are eager to tackle your challenges.